Ghana coach Milovan Rajevac has named his squad for the double World Cup qualifiers this month, handing youngsters Afena-Gyan and Edmund Addo their maiden call-ups.
The Serbian trainer has called up 28 players for the crucial games against Ethiopia and South Africa on November 11 and 14.
Notable names such as Andre Ayew, Jordan Ayew and Thomas Partey were all named in the team.
Meanwhile, there is a return for in-form attacker Richmond Bokye-Yiadom.
Ghana will travel to South Africa to play Ethiopia before finishing off the group with the clash against the Bafana Bafana in Cape Coast.
Below is the squad for the two matches:
Goalkeepers: Joseph Wollacott (Swindon Town), Lawrence Ati-Zigi (St.Gallen), Manaf Nurudeen (Eupen), Richard Attah (Hearts of Oak)
Defenders: Andy Yiadom (Reading FC), Philemon Baffour (Dreams FC), Baba Abdul Rahman (Reading FC), Gideon Mensah (Girondins Bordeaux), Daniel Amartey (Leicester City), Alexander Djiku (Strasbourg), Joseph Aidoo (Celta Vigo), Jonathan Mensah (Columbus Crew), Ismail Abdul Ganiyu (Asante Kotoko)
Midfielders: Baba Idrissu (Real Mallorca), Thomas Partey (Arsenal FC), Mubarak Wakaso (Shenzhen F.C), Edmund Addo (Sheriff Tiraspol), Mohammed Kudus (Ajax Amsterdam), Daniel Kofi Kyere (FC St. Pauli)
Wingers: Andre Ayew (Al Sadd), Jordan Ayew (Crystal Palace), Abdul Fatawu Issahaku (Dreams FC), Kamal Deen Sulemana (Rennes), Samuel Owusu (Al Fayha)
Strikers: Richmond Boakye-Yiadom (Beitar Jerusalem), Benjamin Tetteh (Yeni Malatyaspor), Felix Afena Gyan (AS Roma), Caleb Ekuban (Genoa)